Publication year: 2011
Source: World Neurosurgery, Available online 1 November 2011
Shin-ichiro Sugiyama, Hui Meng, Kenichi Funamoto, Takashi Inoue, Miki Fujimura, ...
ObjectiveThe role of hemodynamics in the growth of intracranial aneurysms is not completely clear. We present a hemodynamic study with 2 adjacent unruptured aneurysms arising from 1 parent artery but growing in different ways. This study aimed to investigate whether there were differences in hemodynamic characteristics between the 2 growing aneurysms.MethodsA 62-year old female patient presented with 6 unruptured intracranial aneurysms. Catheter angiography at 6-month intervals revealed that 2 aneurysms located adjacently at the right posterior inferior cerebellar artery were growing over a 1-year period. Three-dimensional aneurysm geometries were acquired via rotational angiography. Computational fluid dynamic (CFD) simulations were conducted on the 3D aneurysm geometries under patient-specific pulsatile flow conditions that were measured by magnetic resonance velocimetry.ResultsThe proximal multi-lobular aneurysm demonstrated high flow and physiological levels of wall shear stress (WSS) in the region of growth, whereas the distal rounded aneurysm had low flow and low WSS in the growing sac.ConclusionGrowing aneurysms can have heterogeneous hemodynamic and morphologic characteristics and different growing patterns. Growing regions of an aneurysm could be exposed to either high WSS at the inflow zone or low WSS and high oscillatory shear in the aneurysm sac.
No comments:
Post a Comment