Publication year: 2011
Source: World Neurosurgery, Available online 10 November 2011
Maogang Chen, Qizhang Wang, Wusheng Zhu, Qin Yin, Minmin Ma, ...
ObjectiveThis study aimed to evaluate the efficacy and safety of stereotactic aspiration combined with subsequent thrombolysis in treating moderate thalamic hemorrhage (TH).MethodsA total of 105 patients with TH were nonrandomly assigned to the conservative treatment group (n= 60) or to the aspiration group (n= 45). Patients in the aspiration group were treated with stereotactic aspiration plus subsequent thrombolysis for removal for their hematomas.ResultsThe 30-day mortality in the conservative group was significantly higher than that in the aspiration group (28.3% (17/60) vs. 11.2% (5/45),P= 0.032). The rank of the 30-day Glasgow outcome scale in the conservative group was significantly lower than that in the aspiration group (P= 0.041), and the mean 30-day National Institutes of Health Stroke Scale score of the survivors in the conservative group was significantly higher than that in the aspiration group (16.5 ± 4. 2 vs. 14.2 ± 3.9,P= 0.012). There were a greater reduction in TH volume in the aspiration group than in the conservative group from day 1 to day 3 (-0.24% and 39.28%, respectively,P< 0.0001) and from day 1 to day 7 (26.58% and 63.26%, respectively,P< 0.0001). The rank of 90-day Glasgow outcome scale was significantly lower in the conservative group than that in the aspiration group(P= 0.015). Eighteen of 60 patients (30.0%) had a favorable outcome in the conservative group, whereas 23 of 45 patients (51.1%) had a favorable outcome in the aspiration group, and this difference was significant (P= 0.028). The 90-day cumulative mortality rate in the conservative group was significantly higher than that in the aspiration group (33.3% (20/60)) vs. 15.6% (7/45),P= 0.039).ConclusionsStereotactic aspiration plus subsequent thrombolysis is effective and safe for moderate TH.
Source: World Neurosurgery, Available online 10 November 2011
Maogang Chen, Qizhang Wang, Wusheng Zhu, Qin Yin, Minmin Ma, ...
ObjectiveThis study aimed to evaluate the efficacy and safety of stereotactic aspiration combined with subsequent thrombolysis in treating moderate thalamic hemorrhage (TH).MethodsA total of 105 patients with TH were nonrandomly assigned to the conservative treatment group (n= 60) or to the aspiration group (n= 45). Patients in the aspiration group were treated with stereotactic aspiration plus subsequent thrombolysis for removal for their hematomas.ResultsThe 30-day mortality in the conservative group was significantly higher than that in the aspiration group (28.3% (17/60) vs. 11.2% (5/45),P= 0.032). The rank of the 30-day Glasgow outcome scale in the conservative group was significantly lower than that in the aspiration group (P= 0.041), and the mean 30-day National Institutes of Health Stroke Scale score of the survivors in the conservative group was significantly higher than that in the aspiration group (16.5 ± 4. 2 vs. 14.2 ± 3.9,P= 0.012). There were a greater reduction in TH volume in the aspiration group than in the conservative group from day 1 to day 3 (-0.24% and 39.28%, respectively,P< 0.0001) and from day 1 to day 7 (26.58% and 63.26%, respectively,P< 0.0001). The rank of 90-day Glasgow outcome scale was significantly lower in the conservative group than that in the aspiration group(P= 0.015). Eighteen of 60 patients (30.0%) had a favorable outcome in the conservative group, whereas 23 of 45 patients (51.1%) had a favorable outcome in the aspiration group, and this difference was significant (P= 0.028). The 90-day cumulative mortality rate in the conservative group was significantly higher than that in the aspiration group (33.3% (20/60)) vs. 15.6% (7/45),P= 0.039).ConclusionsStereotactic aspiration plus subsequent thrombolysis is effective and safe for moderate TH.
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