Subacute Seizure Incidence in Thrombolysis-treated Ischemic Stroke Patients

Abstract

Background  

To assess the incidence of seizures in acute ischemic stroke patients treated with chemical (tPA) thrombolysis.

Methods  

Retrospective study including all thrombolysis patients treated in Calgary between January 1, 2001, and October 31, 2006. Descriptive statistics and age/sex-adjusted P values were calculated.

Results  

Of 400 eligible patients (median age 74.0 years, range: 24–77), 16 (4%) developed post-stroke seizures: 10 (62.5%) within one week (early) and 6 (37.5%) after 1 week but within the hospital stay (late). Single-vessel anterior circulation involvement (93.8% vs. 87%, P = 0.34) and hemorrhage (37.5% vs. 20%, P = 0.15) were more common in those with compared to without seizures but did not reach statistical significance. Atrial fibrillation was more common in those with (56.3%) than without (36.1%) seizures (P = 0.04). Death during admission was more likely (P = 0.03) in those who sustained seizures (37.5%) compared to those without seizures (17.6%).

Conclusions  

In this cohort of tPA-treated patients, post-stroke seizures were associated with atrial fibrillation and early mortality.

• Content Type Journal Article
• Category Original Article
• Pages 1-5
• DOI 10.1007/s12028-011-9657-x
• Authors
  • P. Couillard, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • M. A. Almekhlafi, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • A. Irvine, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • N. Jetté, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • J. Pow, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • C. St.Germaine-Smith, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • N. Pillay, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada
  • M. D. Hill, Department of Clinical Neurosciences, University of Calgary, Foothills Medical Centre, 1403 29th Street NW, Calgary, AB T2N 2T9, Canada

• Journal Neurocritical Care
• Online ISSN 1556-0961
• Print ISSN 1541-6933

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