Today anesthetics are considered as routine as a trip to the dentist. They have been around at least since the 18th century when a talented chemist named Humphry Davy discovered the mysterious effect of nitrous oxide (laughing gas). Davy, young and ambitious, set out to rigorously test the gas's effect, inhaling nitrous oxide daily for several months. Under slightly less rigorous conditions, Davy shared the gas with a distinguished group of friends including Samuel Taylor Coleridge, James Watt, and Robert Southey--who wrote in a letter that "the atmosphere of the highest of all possible heavens must be composed of this gas." These early trials laid the foundation for anesthesia's emergence in medicine today. Yet in the modern era, despite tremendous advances in the quality and selectivity of anesthetics, we still have a poor understanding of how anesthetics work in the brain.
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