A New Technology for Detecting Cerebral Blood Flow: A Comparative Study of Ultrasound Tagged NIRS an

Abstract  

There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and ¹³³Xenon single photon emission computer tomography (¹³³Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P < 0.001) at 15 min after acetazolamide injection. There was a significant correlation between CFI and SPECT CBF values (r = 0.67 and P ≤ 0.033) at 15 min, but not at 60 min (P ≥ 0.777). UT-NIRS detected an increase in CFI following an acetazolamide bolus, which correlated with CBF measured with ¹³³Xe-SPECT. This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring.

• Content Type Journal Article
• Category Take Notice Technology
• Pages 1-7
• DOI 10.1007/s12028-012-9720-2
• Authors
  • Henrik W. Schytz, Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
  • Song Guo, Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark
  • Lars T. Jensen, Clinical Physiology and Nuclear Medicine, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, Glostrup, Denmark
  • Moshe Kamar, Ornim Medical Ltd., Lod, Israel
  • Asaph Nini, Ornim Medical Ltd., Lod, Israel
  • Daryl R. Gress, Department of Neurology and Neurosurgery, University of Virginia, Charlottesville, VA, USA
  • Messoud Ashina, Danish Headache Center and Department of Neurology, Glostrup Hospital, Faculty of Health Sciences, University of Copenhagen, 2600 Glostrup, Denmark

• Journal Neurocritical Care
• Online ISSN 1556-0961
• Print ISSN 1541-6933

http://www.springerlink.com/content/g357ux0mt2r21234/

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