Publication year: 2012
Source:World Neurosurgery
Adrian W. Laxton, Andres M. Lozano
Objective To review the use of deep brain stimulation (DBS) for the treatment of dementia. Methods A Pubmed literature search was conducted to identify all studies that have investigated the use of DBS for the treatment of dementia. Results Three studies have examined the use of DBS for dementia. One study involved fornix DBS for Alzheimer's disease (AD), and two studies involved DBS of the nucleus basalis of Meynert (NBM), one to treat AD and the other for Parkinson's disease dementia (PDD). Conclusion Evidence for the use of DBS to treat dementia is preliminary and limited. Fornix and NBM DBS can influence activity in the pathological neural circuits that underlie AD and PDD. Further investigation into the potential clinical effects of DBS for dementia is warranted.
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