Publication year: 2012
Source:World Neurosurgery
Ann-Christin von Vogelsang, Yvonne Wengström, Mikael Svensson, Christina Forsberg
Objective To describe epidemiology in relation to gender differences and treatment modalities ten years post intracranial aneurysm rupture in the Stockholm cohort 1996-1999. Methods A total of 468 consecutive aneurysmal subarachnoid hemorrhage patients were followed-up in a retrospective cohort design ten years post rupture. Information on medical history, clinical variables and treatments were obtained from patients records. Causes of death were obtained from patient records and The Swedish Cause of Death Register. Incidence of ruptured aneurysms per 100 000 people were calculated from male, female and overall population data per year from 1996 to 1999. Results Ten years after aneurysm rupture 63.9% ( n = 296) of patients were still alive. The overall 28-day case fatality was 19.4%, deaths were in majority of cases due to the initial hemorrhage. There were no significant differences in survival time between patients treated with clipping (8.4 years, 95% CI: 8.1-8.8), compared to endovascularly treated patients (8.2 years, 95% CI: 7.4-9.1) (log rankP = 0.550). The female incidence was higher than that of men, and women were significantly older at the onset of aneurysm rupture (55.7 vs. 52.8 years,P = 0.027). Conclusion Ten years post rupture, the majority of treated patients were still alive. The mortality was highest in the first month post rupture, due to the initial hemorrhage. Gender differences were apparent in incidence, but ten years following the rupture mortality rates and survival times were equal between men and women. Survival time was equal between patients within active treatment modalities.
Source:World Neurosurgery
Ann-Christin von Vogelsang, Yvonne Wengström, Mikael Svensson, Christina Forsberg
Objective To describe epidemiology in relation to gender differences and treatment modalities ten years post intracranial aneurysm rupture in the Stockholm cohort 1996-1999. Methods A total of 468 consecutive aneurysmal subarachnoid hemorrhage patients were followed-up in a retrospective cohort design ten years post rupture. Information on medical history, clinical variables and treatments were obtained from patients records. Causes of death were obtained from patient records and The Swedish Cause of Death Register. Incidence of ruptured aneurysms per 100 000 people were calculated from male, female and overall population data per year from 1996 to 1999. Results Ten years after aneurysm rupture 63.9% ( n = 296) of patients were still alive. The overall 28-day case fatality was 19.4%, deaths were in majority of cases due to the initial hemorrhage. There were no significant differences in survival time between patients treated with clipping (8.4 years, 95% CI: 8.1-8.8), compared to endovascularly treated patients (8.2 years, 95% CI: 7.4-9.1) (log rankP = 0.550). The female incidence was higher than that of men, and women were significantly older at the onset of aneurysm rupture (55.7 vs. 52.8 years,P = 0.027). Conclusion Ten years post rupture, the majority of treated patients were still alive. The mortality was highest in the first month post rupture, due to the initial hemorrhage. Gender differences were apparent in incidence, but ten years following the rupture mortality rates and survival times were equal between men and women. Survival time was equal between patients within active treatment modalities.
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