Gene Therapy for Psychiatric Disorders

Available online 23 December 2012
Publication year: 2012
Source:World Neurosurgery

Gene therapy has become of increasing interest in clinical neurosurgery with the completion of numerous clinical trials for Parkinson's disease, Alzheimer's disease and pediatric genetic disorders. With improved understanding of the dysfunctional circuitry mediating a variety of psychiatric disorders, deep brain stimulation for refractory psychiatric diseases is being increasingly explored in human patients. This combination of factors is therefore likely to facilitate development of gene therapy for psychiatric diseases. Since delivery of gene therapy agents will require the same surgical techniques currently being employed for deep brain stimulation, neurosurgeons will likely lead the development of this field as has occurred in other areas of clinical gene therapy for neurological disorders. Here we will review the current state of gene therapy for psychiatric disorders, and will focus specifically upon particular areas of promising research that may translate into human trials for depression, drug addiction, obsessive-compulsive disorder and schizophrenia. Issues that are relatively unique to psychiatric gene therapy will also be discussed.

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Júlio Leonardo B. Pereira

http://lattes.cnpq.br/7687651239699170

http://www.neurocirurgiabr.com