Available online 11 January 2013
Publication year: 2013
Source:Neuroscience & Biobehavioral Reviews
The social and economic impact of mood disorders and suicide is extremely high and may be even higher in coming years, and yet, research in mental health is largely underfunded. This report summarizes the most recent data concerning the epidemiology and burden of depression and suicide, and underlines the most recent initiatives to identify the barriers to effective treatment and prevention of mood disorders. Global cooperation and networks of research networks are proposed. Progress in the understanding of the pathophysiology and subtypes of depression, technological advances, emphasis on early prediction of response and prevention, and a paradigm shift in drug development are crucial to overcome the current challenges posed by increasing rates of depression and suicide.
Highlights
► The social and economic impact of mood disorders and suicide is increasingly high. ► Affective disorders are the most important contributors to the global burden of all diseases. ► Some efforts, such as new classifications and drug development seem to be failing. ► Global cooperation and networks of research networks may be crucial for success. ► More funding and a paradigm shift in drug development may be necessary.
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