Available online 4 January 2013
Publication year: 2013
Source:World Neurosurgery
Objective Outcome of patients with aneurysmal subarachnoid hemorrhage (SAH) has improved slowly over the past 25 years. The reasons for this may include early aneurysm repair by endovascular or open means, use of nimodipine and better critical care management. Despite this, mortality remains at about 40% and many survivors have permanent neurological, cognitive and neuropsychological deficits. Randomized clinical trials have tested pharmacological therapies but few have been successful. There are numerous explanations for the failure of these trials, such as truly ineffective interventions, inadequate sample size, treatment side effects, or insensitive or inappropriate outcome measures. Outcome often is evaluated on a good-bad dichotomous scale developed for traumatic brain injury 40 years ago. Methods To address these, we established the Subarachnoid Hemorrhage International Trialists Data Repository (SAHIT). Results The primary aim of SAHIT is to provide a unique resource for prognostic analysis and for studies aimed at optimizing the design and analysis of phase III trials in aneurysmal SAH. With this in mind, we convened a multinational investigator meeting to explore merging individual patient data from multiple clinical trials and observational databases of patients with SAH, and to create an agreement under which such a group of investigators could submit data and collaborate. Conclusions We welcome collaboration with other investigators.
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