The role of Stat3 in glioblastoma multiforme

Publication date: Available online 17 May 2013
Source:Journal of Clinical Neuroscience
Author(s): Rodney B. Luwor , Stanley S. Stylli , Andrew H. Kaye
Glioblastoma multiforme (GBM) is the most common brain tumor and has the worst prognosis. Several signaling molecules have been clearly implicated in the development, progression, and aggressiveness of GBM. Here we review the role of signal transducer and activator of transcription-3 (Stat3) in GBM. We particularly focus on its expression in clinical GBM samples, its role in brain tumorigenicity in cell lines and animal models, and discuss possible therapeutic strategies targeting Stat3. This review also summarizes the current knowledge regarding the role of Stat3 regulation by upstream activators and repressors in promoting GBM progression in both translational and clinical studies.

http://rss.sciencedirect.com/action/redirectFile?&zone=main¤tActivity=feed&usageType=outward&url=http%3A%2F%2Fwww.sciencedirect.com%2Fscience%3F_ob%3DGatewayURL%26_origin%3DIRSSSEARCH%26_method%3DcitationSearch%26_piikey%3DS0967586813001987%26_version%3D1%26md5%3D2c937a47134863cc3a21dc923a00ffac

Sent with MobileRSS for iPhone

Julio Pereira, MD

Phone: (+1) 424-2301706

Linkedin:http://www.linkedin.com/in/juliommais 

Site: www.neurocirurgiabr.com