Mood disorders: A new target for antidepressant drugs
Nature Reviews Neuroscience - Issue - nature.com science feeds
Nature Reviews Neuroscience 14, 520 (2013). doi:10.1038/nrn3554
Author: Monica Hoyos Flight
The mechanisms of action of most antidepressants are unclear. A study in Nature Medicine now shows that therapeutic concentrations of the antidepressants amitriptyline and fluoxetine reduced the activity of acid sphingomyelinase (ASM), an enzyme that releases ceramide from sphingomyelin, in both cultured neurons and
Original Article: http://feeds.nature.com/~r/nrn/rss/current/~3/APK53uJVxDY/nrn3554
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