A physiologic biomarker for cerebral amyloid angiopathy
Neurology recent issues
Cerebral amyloid angiopathy (CAA), a common small-vessel disease of older adults characterized by accumulation of amyloid-β in leptomeningeal and cortical blood vessels, is a well-established cause of intracerebral hemorrhage.1 Recent years have seen the emergence of clinical research reports establishing associations between CAA, ischemic brain injury, and vascular cognitive impairment (VCI). CAA patients had a higher load of chronic microvascular white matter hyperintensities (WMH), small infarcts, as well as a high degree of WMH progression.2,3 A more recent report showed that vascular amyloid load strongly correlated with ischemic WMH in CAA.4
Original Article: http://www.neurology.org/cgi/content/short/81/19/1650?rss=1
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