https://itunes.apple.com/br/app/diagnose/id599854243?mt=8
Monday, December 30, 2013
App: Diagnose
https://itunes.apple.com/br/app/diagnose/id599854243?mt=8
Sunday, December 29, 2013
Carpal Tunnel Syndrome in Children
Abstract: Background: Carpal tunnel syndrome or median neuropathy at the wrist is a rare condition in children. Of the reported patients with carpal tunnel syndrome, mucopolysaccharidoses and the mucolipidoses are the most common causes.Patients: We report 13 patients between the ages of 2 and 17 years of age with carpal tunnel syndrome.Results: Mucopolysaccharidoses was the cause in one child. In other children, trauma to the median nerve, malformations of the wrist, brachial plexopathy, obesity, inherited susceptibility to pressure palsies (PMP 22 gene deletion), and family history of median neuropathy at the wrist were identified. All patients had hand pain, numbness, and paresthesias in their hands. The nerve conduction studies showed prolongation of median sensory nerve latency and distal motor latency in median nerve.Conclusions: Carpal tunnel syndrome occurs in children and a variety of risk factors predispose to its occurrence.
Original Article: http://www.pedneur.com/article/S0887-8994(13)00544-4/abstract?rss=yes
Brain Abscess as a Cause of Macrocephaly in a Newborn
A 5-month-old boy with no remarkable prior medical problems was referred for evaluation of macrocephaly. The growth in head circumference, developed over several weeks, was apparently asymptomatic, but even basic recall and history-taking was hampered by idiomatic and social barriers with the patient's family. Examination revealed a febrile patient (38.1°C) with a head circumference of 45 cm, tense fontanelle, and downward gaze. The rest of his examination was normal, including pupil size and reactivity, limb mobilization, and alimentation. Blood and urine analysis was relevant only for leukocytosis (26.4 × 103/mm3 [7.5-13.5]) and a C-reactive protein of 62.2 mg/L (<15). Blood and urine cultures were negative. No local, distant, or procedural infection, present or recent, was identified. Magnetic resonance imaging of the brain revealed a lesion in the right hemisphere with severe mass effect on all intracranial structures ( A). An urgent burr-hole craniostomy allowed catheterization of an abscess and drainage of 100 mL of pus. Antibiotics were injected and drained. Intravenous antibiotics were started. Microbiology of the abscess was positive for Staphylococcus aureus. Despite a favorable clinical course, a repeated surgical drainage was necessary to obtain radiologic resolution of the abscess ( B).
Original Article: http://www.pedneur.com/article/S0887-8994(13)00557-2/abstract?rss=yes
Anxiety Linked to Increased Stroke Risk
High anxiety levels were associated with an increased risk for incident stroke independent of other risk factors, including depression, in a new prospective study.
Medscape Medical News
Original Article: http://www.medscape.com/viewarticle/818373?src=rss
More Evidence Links Head Trauma to Alzheimer's Pathology
A new study finds that a history of head trauma is associated with Alzheimer's-type brain changes among people with mild cognitive impairment.
Medscape Medical News
Original Article: http://www.medscape.com/viewarticle/818376?src=rss
Saturday, December 28, 2013
The top 10 quick reference medical apps for iPhone released in 2013
The top 10 quick reference medical apps for iPhone released in 2013
by Iltifat Husain, MD
Friday, December 27, 2013
Neurosurgery Blog partilhou contigo uma foto do Instagram
Neurosurgery Blog acabou de partilhar contigo uma foto do Instagram:
view full image
"Subdural Empiema. Neuroinfect app #neurosurgeryblog"
A Equipa do Instagram
Wednesday, December 25, 2013
App Essential Skeleton 2
https://itunes.apple.com/br/app/essential-skeleton-2/id623811668?l=en&mt=8
3D Brain App
https://itunes.apple.com/br/app/3d-brain/id331399332?l=en&mt=8
AANS Grand Rounds
https://itunes.apple.com/br/app/aans-grand-rounds/id572405215?l=en&mt=8
Tuesday, December 24, 2013
Elsevier Announces the Launch of Open Access Journal - Sacramento Bee
Elsevier Announces the Launch of Open Access Journal Sacramento Bee Elsevier, a world-leading provider of scientific, technical and medical information, products and solutions announces the launch of open access journal, Interdisciplinary Neurosurgery: Advanced Techniques and Case Management. Neurosurgery has recently ... |
Original Article: http://news.google.com/news/url?sa=t&fd=R&usg=AFQjCNG2oR9uRZt-q1XfYbom7sQR3202Hg&url=http://www.sacbee.com/2013/12/23/6022517/elsevier-announces-the-launch.html
Monday, December 23, 2013
Stem cell therapy for spinal cord injury
A systematic survey of the scientific literature shows that stem cell therapy can have a statistically significant impact on animal models of spinal cord injury, and points the way for future studies.
Original Article: http://www.medicalnewstoday.com/releases/270349.php
Sunday, December 22, 2013
Start Warfarin, Have a Stroke? (CME/CE)
(MedPage Today) -- Starting warfarin for preventing stroke in patients with atrial fibrillation appeared to be associated with a transiently increased risk of ischemic stroke before the preventive effects kicked in, a large case-control study showed.
Original Article: http://www.medpagetoday.com/Cardiology/Arrhythmias/43544
The Impact of Body Mass Index on Hospital Stay and Complications After Spinal Fusion
BACKGROUND: Obesity is a dominant public health concern and risk factor for disability, with few studies examining its impact in spinal surgery. Patients with a higher body mass index (BMI) have lower functional status, increased pain, and worse physical condition than those with ideal weight. OBJECTIVE: To determine associations between BMI categories on adverse patient outcomes after long-segment spinal fusions. METHODS: Consecutive, open, elective fusions (interbody and/or posterolateral arthrodesis) of more than 5 levels from 2007 to 2010 were retrospectively analyzed with follow-up of more than 1 year. Bivariate analyses examined outcome variables based on BMI categories. Linear regression analysis evaluated BMI, hospital stay, and complications at 1 and 2 years, controlling for confounders. Mean and median follow-up lengths were 2.1 and 2.0 years, respectively. RESULTS: A total of 189 surgeries on 112 patients, with a mean age of 59.5 years and a mean BMI of 29.8 kg/m2, were analyzed. Morbidly obese patients had longer hospitalizations, worse Oswestry Disability Index (ODI), and more complications at 1 and 2 years than ideal weight patients. Multivariate linear regression modeling revealed sex, cardiac medications, cerebrospinal fluid leak, and BMI category of ideal vs nonideal influenced hospitalization length. Multivariate analysis showed BMI greater than 30 kg/m2, preoperative ODI, and pedicle subtraction osteotomy influenced all complications at 1 year. Mean complications at 2 years for the morbidly obese were 3 times more than those underweight and 8 times more than those with ideal weight. Controlling for age, sex, and length of stay, obese and morbidly obese patients had more complications at 2 years; morbidly obese patients had a worse 2-year ODI. CONCLUSION: BMI is an independent predictor of hospitalization length and all complications at 1 and 2 years in patients receiving long-segment fusions. ABBREVIATION: ODI, Oswestry Disability Index PSO, pedicle subtraction osteotomy
Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/01000/The_Impact_of_Body_Mass_Index_on_Hospital_Stay_and.6.aspx
Patients in vegetative state able to recognize loved ones' faces
New research suggests that the brains of patients in a vegetative state - meaning patients are awake with no signs of awareness - may be able to recognize photographs of friends and family, and make emotional connections. This is according to a study published in the journal PLOS One.
Original Article: http://www.medicalnewstoday.com/articles/270404.php
Saturday, December 21, 2013
Outcomes After Anterior or Complete Corpus Callosotomy in Children
BACKGROUND: Corpus callosotomy (CC) is a valuable palliative surgical option for children with medically refractory epilepsy due to generalized or multifocal cortical seizure onset. OBJECTIVE: To investigate the extent of CC resulting in optimal seizure control in a pediatric patient population and to evaluate the modification of seizure profile after various CC approaches. METHODS: The records of 58 children (3-22 years of age at the time of surgery) with medically refractory epilepsy who underwent CC between 1995 and 2011 were retrospectively reviewed. RESULTS: Anterior two thirds callosotomy resulted in resolution of absence (P = .03) and astatic (P = .03) seizures, whereas anterior two thirds callosotomy followed by second-stage completion resulted in resolution of generalized tonic-clonic (GTC) (P = .03), astatic (P = .005), and myoclonic (P = .03) seizures in addition to a trend toward resolution of absence seizures (P = .08). Single-stage upfront complete callosotomy resulted in resolution of absence (P = .002), astatic (P < .0001), myoclonic (P = .007), and complex partial (P = .008) seizures in addition to a trend toward resolution of GTC (P = .06). In comparing a composite of subjects who underwent anterior two thirds callosotomy alone or 2-stage complete callosotomy before the second stage to complete the callosotomy with subjects who underwent upfront complete CC, a more favorable outcome was found in those with the upfront complete CC (P = .02). CONCLUSION: Single-stage upfront complete callosotomy is effective in relieving a broader spectrum of seizure types than anterior two thirds callosotomy or 2-stage complete callosotomy in children. The advantages of single-stage complete callosotomy must be weighed against the potentially higher risk of neurological and operative complications. ABBREVIATIONS: CC, corpus callosotomy CPS, complex partial seizure GTC, generalized tonic-clonic SPS, simple partial seizure VNS, vagal nerve stimulation
Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/01000/Outcomes_After_Anterior_or_Complete_Corpus.3.aspx
Ventriculoperitoneal Shunt 30-Day Failure Rate: A Retrospective International Cohort Study
BACKGROUND: With the need for transparency of surgical results, 30-day outcome measures have become increasingly important. Ventriculoperitoneal (VP) shunt failure is a substantial burden to patients and health care systems. OBJECTIVE: This study introduces the 30-day VP shunt failure rate as a possible barometer of surgical outcome and demonstrates its use in a national (United Kingdom [UK]) study and makes comparison with 2 published randomized, controlled trials (RCT). METHODS: A cohort study of all (except 1) pediatric neurosurgical centers in the UK and Ireland. All new and revision VP shunt operations were recorded for 2008 and 2009. Both newly placed and revised VP shunts were subject to Kaplan-Meier analysis, and 30-day failure rate was obtained. Data from 2 RCTs investigating new VP shunt technology were analyzed, and the 30-day failure rate was extracted for comparative purposes. RESULTS: The overall 30-day and 1-year failure rates for new shunts were 12.9% and 28.8%, respectively. The 30-day failure rate from 2 RCTs was comparable (14% and 16%, respectively). The failure rate of the subsequent revision of those new shunts was 20.7% at 30 days and 40.4% at 1 year. According to these data, shunt survival appears to be better if performed by a consultant pediatric neurosurgeon for revision surgery only. CONCLUSION: VP shunt survival in the UK is comparable to the published multicenter data investigating shunt survival. The 30-day failure rate may represent a better barometer of surgical outcome and should be used as a separate outcome measure in the design of future trials. ABBREVIATIONS: CI, confidence interval RCT, randomized controlled trial UK, United Kingdom VP, ventriculoperitoneal shunt
Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/01000/Ventriculoperitoneal_Shunt_30_Day_Failure_Rate___A.4.aspx
Monitoring Flow in Extracranial-Intracranial Bypass Grafts Using Duplex Ultrasonography: A Single-Center Experience in 80 Grafts Over 8 Years
BACKGROUND: High-flow extracranial-intracranial (EC-IC) bypass is performed by using radial artery graphs (RAGs) or saphenous vein grafts (SVGs) for various pathologies such as aneurysms, ischemia, and skull-base tumors. Quantifying the acceptable amount of blood flow to maintain proper cerebral perfusion has not been well established, nor have the variables that influence flow been determined. OBJECTIVE: To identify the normative range of blood flow through extracranial-intracranial RAGs and SVGs as measured by duplex ultrasonography. Multiple variables were evaluated to better understand their influence of graft flow. METHODS: All EC-IC grafts performed at Harborview Medical Center from 2005 to 2012 were retrospectively reviewed for this cohort study. Daily extracranial graft duplex ultrasonography with flow volumes and transcranial graft Doppler were examined, as were short- and long-term outcomes. Both ischemic and hyperemic events were evaluated in further detail. RESULTS: Eighty monitorable high-flow EC-IC bypasses were performed over the 8-year period. Sixty-five bypasses were performed by using RAGs and 15 were performed with SVGs. The average flow was 133 mL/min for RAGs and 160 mL/min for SVGs (P = .25). For both RAG and SVG groups, the donor and recipient vessel selected significantly impacted flow. For the RAG group only, preoperative graft diameter, postoperative hematocrit, and postoperative date significantly influenced flow. A 1-week average of >200 mL/min was 100% sensitive to cerebral hyperemia syndrome. CONCLUSION: This study establishes the normative range of duplex ultrasonographic flow after high-flow EC-IC bypass, as well the usefulness and practicality of such monitoring as a surrogate to flow in the postoperative period. ABBREVIATIONS: CHS, cerebral hyperperfusion syndrome CTA, computed tomographic angiography ECA, external carotid artery EC-IC, extracranial-intracranial ICA, internal carotid artery MCA, middle cerebral artery OA, occipital artery RAG, radial artery graft STA, superficial temporal artery SVG, saphenous vein graft TCD, transcranial Doppler TIA, transient ischemic attack
Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/01000/Monitoring_Flow_in_Extracranial_Intracranial.8.aspx
Multimodality Treatment of Complex Unruptured Cavernous and Paraclinoid Aneurysms
BACKGROUND: Unruptured aneurysms of the cavernous and paraclinoid internal carotid artery can be approached via microsurgical and endovascular approaches. Trends in treatment reflect a steady shift toward endovascular techniques. OBJECTIVE: To analyze our results with multimodal treatment. METHODS: We reviewed patients with unruptured cavernous and paraclinoid internal carotid artery aneurysms proximal to the posterior communicating artery treated at a single center from 2007 to 2012. Treatment included 4 groups: (1) stent-assisted coiling, (2) pipeline endovascular device (PED) flow diverter, (3) clipping, and (4) trapping/bypass. Follow-up was 2 to 60 months. RESULTS: The 109 aneurysms in 102 patients were studied with the following treatment groupings: 41 were done with stent-assisted coiling, 24 with Pipeline endovascular device, 24 by microsurgical clipping, and 20 by trap/bypass. Group: (1) two percent had delayed significant intraparenchymal hemorrhage; (2) thirteen percent had central nerve palsies, 8% had small asymptomatic infarcts, and 4% had small, asymptomatic remote-site hemorrhages; (3) twenty-nine percent of patients suffered from transient central nerve palsies, 4% experienced major stroke, and 8% had small intracerebral hemorrhages; (4) thirty-five percent had transient central nerve palsies, 10% had strokes, and 10% had intracerebral hemorrhages. In terms of follow-up obliteration, 83% had complete/nearly complete obliteration at last follow-up, 17% had residual aneurysms, and 10% required retreatment. Ninety-six percent of group 1 (35/38), 100% of group 2 (23/23), 100% of group 3 (21/21), and 95% of group 4 had modified Rankin Scale scores of 0 to 1. CONCLUSION: Treatment of these aneurysms can be carried out with acceptable rates of morbidity. Careful patient selection is crucial for optimal outcome. Endovascular treatment volumes likely will continue to predominate over microsurgical techniques as changing skill sets evolve in neurosurgery, but individualized application of all available treatment options will continue. ABBREVIATIONS: ICA, internal carotid artery MCA, middle cerebral artery mRS, modified Rankin Scale PED, Pipeline Embolization Device
Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/01000/Multimodality_Treatment_of_Complex_Unruptured.7.aspx
Cognard Type V Intracranial Dural Arteriovenous Shunt: Case Reports and Literature Review With Special Consideration of the Pattern of Spinal Venous Drainage
BACKGROUND AND IMPORTANCE: Prompt diagnosis of intracranial dural arteriovenous shunt (DAVS) with spinal venous drainage, classified as Cognard type V, is difficult. We investigated the angiographic and magnetic resonance imaging (MRI) characteristics of Cognard type V DAVS to determine the reason for the difficulty in early diagnosis. CLINICAL PRESENTATION: We systematically reviewed 54 published and 3 new cases of Cognard type V DAVS. The pattern of venous drainage was classified on the basis of relative dominance of the anterior and posterior spinal veins with the use of angiograms. T2-weighted sagittal MRIs were used to detect signal flow voids of enlarged spinal veins. Types of venous drainage were determined in 49 of the 57 cases. Twenty-eight and 8 cases showed a dominance of anterior and posterior spinal venous drainage, respectively. In 13 cases, venous drainage was equally distributed through the anterior and posterior spinal veins. Of 41 cases with an abnormally dilated anterior spinal vein, MRIs were available for 25 cases. Signal flow voids of enlarged anterior spinal veins were detected in 9 cases (36.0%), whereas dilatation of the posterior spinal veins was apparent in 9 of 16 cases (56.3%). Overall, MRI detected enlargement of either anterior or posterior spinal veins in 15 of 41 cases (36.6%). CONCLUSION: In Cognard type V DAVS, anterior venous drainage is dominant. Because the anterior spinal veins are located subpially, flow voids are less prominent on sagittal T2-weighted MRI. This may lead to difficulties in diagnosing. Evaluation with MR angiography may compensate for these limitations. ABBREVIATIONS: DAVS, dural arteriovenous shunt MRA, magnetic resonance angiography
Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/01000/Cognard_Type_V_Intracranial_Dural_Arteriovenous.16.aspx
Glaxo Decision Precedes Obamacare Rollout
Pharmaceutical giant GlaxoSmithKline's announcement on December 16 that it will cease paying doctors to promote its products took the medical community by surprise, but the plan appears to have been in the works for some time.
Employing doctors to promote brand-name drugs at conferences has been an industry standard for decades, and many researchers and consumer advocates claim that the practice creates an unethical conflict of interest. The Physician Payment Sunshine Act, a provision of the 2010 Affordable Care Act, requires drug manufacturers to report these payments to the federal government. In an effort to increase transparency the data will be published online starting next year.
[More]Original Article: http://www.scientificamerican.com/blog/post.cfm?id=glaxo-decision-to-end-promotional-payments-to-physicians-precedes-obamacare-rollout
Neurocriminology: implications for the punishment, prediction and prevention of criminal behaviour
Nature Reviews Neuroscience 15, 54 (2014). doi:10.1038/nrn3640
Authors: Andrea L. Glenn & Adrian Raine
Criminal behaviour and violence are increasingly viewed as worldwide public health problems. A growing body of knowledge shows that criminal behaviour has a neurobiological basis, and this has intensified judicial interest in the potential application of neuroscience to criminal law. It also gives rise to
Original Article: http://feeds.nature.com/~r/nrn/rss/current/~3/HFnKIH4Qi-k/nrn3640
Sleep s Role in Obesity, Schizophrenia, Diabetes...Everything
Is sleep good for everything? Scientists hate giving unqualified answers. But the more sleep researchers look, the more the answer seems to be tending toward a resounding affirmative.
The slumbering brain plays an essential role in learning and memory, one of the findings that sleep researchers have reinforced repeatedly in recent years. But that's not all. There's a growing recognition that sleep appears to be involved in regulating basic metabolic processes and even in mental health. Robert Stickgold , a leading sleep researcher based at Harvard Medical School, gives a pr?cis here of the current state of sommeil as it relates to memory, schizophrenia, depression, diabetes–and he even explains what naps are good for.
[More]Original Article: http://www.scientificamerican.com/blog/post.cfm?id=sleeps-role-in-obesity-schizophrenia-diabetes-everything
Why being impulsive might put you at risk for food addiction
An impulsive personality has long been associated with addiction to alcohol and drugs. Impulsive people are more likely to act rashly when they are feeling bad, for example, making them more likely to use drugs or alcohol when they experience a low. Now, psychologists think impulsivity may lead to another problematic behavior – addictive eating.
People with an impulsive personality were found to be more likely to have a food addiction in a recent study by University of Georgia researchers published in the journal Appetite. People reporting higher levels of food addiction were also more likely to have a higher body mass index (BMI). In other words, impulsive people weren't necessarily overweight, but impulsivity was associated with a compulsive relationship with food and, as a result, less healthy weight.
[More]Original Article: http://www.scientificamerican.com/blog/post.cfm?id=why-being-impulsive-might-put-you-at-risk-for-food-addiction
Anxiety Linked to Higher Stroke Risk (CME/CE)
(MedPage Today) -- Anxiety was found to increase stroke risk in a dose-dependent manner independent of depression and cardiovascular risk factors in a new study.
Original Article: http://www.medpagetoday.com/Cardiology/Strokes/43542
Thursday, December 19, 2013
The Confidential Inquiry into premature deaths of people with intellectual disabilities in the UK: a population-based study.
- Heslop P, Blair PS, Fleming P, et al.
- The Confidential Inquiry into premature deaths of people with intellectual disabilities in the UK: a population-based study. [JOURNAL ARTICLE]
- Lancet 2013 Dec 10.
Original Article: http://www.unboundmedicine.com/medline/citation/24332307/The_Confidential_Inquiry_into_premature_deaths_of_people_with_intellectual_disabilities_in_the_UK:_a_population_based_study_
Deep brain stimulation may help Parkinson's patients with driving
According to the Parkinson's Disease Foundation, approximately 1 million people in the US live with the disorder. The disease primarily affects a person's movement, which can make it hard to carry out daily tasks. But new research suggests that deep brain stimulation may help Parkinson's sufferers with one activity - driving.
Original Article: http://www.medicalnewstoday.com/articles/270109.php
Narcolepsy Confirmed as Autoimmune Disease
As the H1N1 swine flu pandemic swept the world in 2009, China saw a spike in cases of narcolepsy -- a mysterious disorder that involves sudden, uncontrollable sleepiness. Meanwhile, in Europe, around 1 in 15,000 children who were given Pandemrix -- a now-defunct flu vaccine that contained fragments of the pandemic virus -- also developed narcolepsy, a chronic disease.
[More]Original Article: http://www.scientificamerican.com/article.cfm?id=narcolepsy-confirmed-as-a-autoimmune-disease
The Top 10 Sciences Stories of 2013
So many stories, so few slots. Our picks this year run the gamut from physics to biology to technology. But as a group, climate change wins in terms of having the most stories, followed by space science.
[More]Original Article: http://www.scientificamerican.com/article.cfm?id=top-10-science-stories-2013