OBJECTIVE:In this study we compare anti-epileptic drug (AED) treatment of intellectually disabled (ID) patients and those with normal intellect (NI).DESIGN/METHODS:We reviewed the medical records of 100 epilepsy patients (50 ID and 50 NI and comparatively severe epilepsy), and recorded all current and past AEDs prescribed for epilepsy.RESULTS:Patients with ID were currently taking a greater number of AEDs (p=0.0001) and had been exposed to more AEDs in the past (p=0.005). There were no significant differences between the two groups in terms of past or present exposure to the newer AEDs as a group (lamotrigine, topiramate, levetiracetam, gabapentin, felbamate and tiagabine). Patients with ID were more likely to be currently taking an old AED (phenobarbital, primidone, phenytoin, carbamazepine or valproic acid) (p=0.01). More ID patients were currently taking (p=0.002) and had previously taken (p=0.004) a benzodiazepine (BZD) AED such as clonazepam, nitrazepam and clobazam.CONCLUSIONS:Patients with ID were currently taking a greater number of AEDs (p=0.0001) and had been exposed to more AEDs in the past (p=0.005). There were no significant differences between the two groups in terms of past or present exposure to the newer AEDs as a group (lamotrigine, topiramate, levetiracetam, gabapentin, felbamate and tiagabine). Patients with ID were more likely to be currently taking an old AED (phenobarbital, primidone, phenytoin, carbamazepine or valproic acid) (p=0.01). More ID patients were currently taking (p=0.002) and had previously taken (p=0.004) a benzodiazepine (BZD) AED such as clonazepam, nitrazepam and clobazam.
Disclosure: Dr. Fridhandler has nothing to disclose. Dr. Coelho has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Jette has nothing to disclose. Dr. Andrade has nothing to disclose.
Original Article: http://www.neurology.org/cgi/content/short/82/10_Supplement/P3.255?rss=1
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