Friday, May 16, 2014

[Comment] Are statins to be STASHed in subarachnoid haemorrhage?

[Comment] Are statins to be STASHed in subarachnoid haemorrhage?
The Lancet Neurology

In The Lancet Neurology, Peter Kirkpatrick and colleagues report the results of an important randomised trial of simvastatin treatment for aneurysmal subarachnoid hemorrhage (SAH). Unfortunately, simvastatin 40 mg per day, started within 96 h of subarachnoid haemorrhage and given for up to 21 days, had no effect on outcome measured on the modified Rankin Scale at 6 months. The only secondary endpoint improved by statin use was a reduction in need for extended hypervolaemic treatment, which is of unknown clinical importance because it emerges alone among other measures that should be associated with delayed cerebral ischaemia.

Original Article: http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70095-X/fulltext?rss=yes

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