Wednesday, May 7, 2014

Stereotactic lesioning in focal epilepsy or less is more--but why has it not worked in the past?

Stereotactic lesioning in focal epilepsy or less is more--but why has it not worked in the past?
Journal of Neurology, Neurosurgery & Psychiatry current issue

Cossu and colleagues present their outcome of stereotactic radiofrequency lesioning in nodular heterotopia and show a remarkable rate of Engel class I outcome. This adds to the growing volume of publications using stereotactic invasive lesioning combined with high-resolution MRI and invasive stereotactic EEG (SEEG) recordings allowing for a three-dimensional physiological characterisation of the epileptogenic focus techniques used. These are radiofrequency thermoablation, laser–guided thermoablationand interstitial radiosurgery, and entities-treated range from hippocampal sclerosis to nodular heterotopias to hypothalamic hamartomas.

Stereotactic radiofrequency lesioning in focal epilepsy has been tried in the past relying on anatomy, brain atlases and some limited depth recordings but was only marginally effective. So what brought on the changes? A combination of techniques, which in conjunction, resulted in a critical mass of information that allowed not only precise targeting of the epileptogenic zone but a reasonable assessment of...

Original Article: http://jnnp.bmj.com/cgi/content/short/85/6/594?rss=1

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