Judgment is not ignorance
Neurology recent issues
We disagree with the statement that "There would be little justification for using RNS or DBS prior to VNS."1 In fact, the efficacy of both deep brain stimulation (DBS) and responsive neurostimulation (RNS) was superior to that of vagus nerve stimulation (VNS) in the respective pivotal clinical trials, an important result given that trials of the DBS and RNS were properly blinded and had strict entry criteria requiring proof that enrolled participants had epileptic seizures. Additionally, patient subgroups with bilateral independent temporal onsets did better than participants as a whole in both the RNS and DBS trials, suggesting that cranially implanted devices may be preferred to VNS in specific clinical situations.
Original Article: http://www.neurology.org/cgi/content/short/83/9/847?rss=1
Júlio Pereira
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