[Review] The role of iron in brain ageing and neurodegenerative disorders
The Lancet Neurology
In the CNS, iron in several proteins is involved in many important processes such as oxygen transportation, oxidative phosphorylation, myelin production, and the synthesis and metabolism of neurotransmitters. Abnormal iron homoeostasis can induce cellular damage through hydroxyl radical production, which can cause the oxidation and modification of lipids, proteins, carbohydrates, and DNA. During ageing, different iron complexes accumulate in brain regions associated with motor and cognitive impairment.
Original Article: http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70117-6/abstract?rss=yes
Júlio Pereira
www.weneuro.com
www.linkedin.com/in/juliommais
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