[Review] Controversies in HIV-associated neurocognitive disorders
The Lancet Neurology
Cross-sectional studies show that around half of individuals infected with HIV-1 have some degree of cognitive impairment despite the use of antiretroviral drugs. However, prevalence estimates vary depending on the population and methods used to assess cognitive impairment. Whether asymptomatic patients would benefit from routine screening for cognitive difficulties is unclear and the appropriate screening method and subsequent management is the subject of debate. In some patients, HIV-1 RNA can be found at higher concentrations in CSF than in blood, which potentially results from the poor distribution of antiretroviral drugs into the CNS.
Original Article: http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70137-1/abstract?rss=yes
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