Resting-state fMRI sheds light on neural substrates of cognitive decline in Parkinson disease
Neurology current issue
Connectivity is a distinctive feature of the brain, and the integrity of functional network dynamics is crucial for normal functioning. Resting-state functional MRI (RS-fMRI) is a measure of spontaneous low-frequency (<0.08–0.1 Hz) fluctuations in the blood oxygen level–dependent (BOLD) signal while the patient lies quietly in the scanner without doing any specific task.1 Functional connectivity is defined by temporal correlations of the BOLD signal between spatially distinct brain regions. RS-fMRI can be obtained in about 8 minutes and added to the structural MRI most patients receive as part of a routine acquisition, although the data analysis is time-consuming and needs expertise.
Original Article: http://www.neurology.org/cgi/content/short/83/22/2000?rss=1
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