Sunday, February 16, 2014

Check out Grays Anatomy Student Edition for iPad

Grays Anatomy Student Edition for iPad

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Grays Anatomy Student Edition for iPad

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Category: Medical

Updated: 15 Nov 2011

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Júlio Leonardo B. Pereira

Saturday, February 15, 2014

Clinical Reasoning: An unusual cause of transverse myelitis?

Clinical Reasoning: An unusual cause of transverse myelitis?
Neurology current issue

A 71-year-old woman presented with a 1-week history of progressive weakness involving her lower extremities, leading to an inability to walk. She also noticed diminished sensation in her lower extremities. She did not complain of bowel or bladder dysfunction. She did not have any neurologic symptoms in her upper extremities. She experienced an upper respiratory tract infection 5 days prior to the start of these symptoms and was treated with antibiotics. There was no history of headache, impaired cognition, or speech impairment.



Original Article: http://www.neurology.org/cgi/content/short/82/6/e46?rss=1

Advances and Surgical Considerations in the Treatment of Moyamoya Disease

Advances and Surgical Considerations in the Treatment of Moyamoya Disease
Neurosurgery - Most Popular Articles

image Moyamoya is a rare disorder that involves steno-occlusive arterial changes of the anterior circulation, along with proliferative development of basal arterial collaterals. It is either idiopathic (called moyamoya disease) or the result of a specific underlying condition such as atherosclerosis, radiation therapy, or sickle cell disease (called moyamoya syndrome or phenomenon). In recent years, numerous insights into and advances in the understanding, evaluation, and management of moyamoya patients have occurred. This article briefly reviews the spectrum of moyamoya conditions and then provides a synopsis of numerous recent investigations that shed light on various aspects of the disease, including its clinical characteristics, natural history, underlying pathology, imaging, surgical techniques, and long-term patient outcome. ABBREVIATIONS: CBF, cerebral blood flow EDAS, encephaloduroarteriosynangiosis MCA, middle cerebral artery MMD, moyamoya disease STA, superficial temporal artery TIA, transient ischemic attack

Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/02001/Advances_and_Surgical_Considerations_in_the.14.aspx

Endovascular Advances for Extracranial Carotid Stenosis

Endovascular Advances for Extracranial Carotid Stenosis
Neurosurgery - Most Popular Articles

image Carotid artery stenting has become a viable alternative to carotid endarterectomy in the management of carotid stenosis. Over the past 20 years, many trials have attempted to compare both treatment modalities and establish the indications for each one, depending on clinical and anatomic features presented by patients. Concurrently, carotid stenting techniques and devices have evolved and made endovascular management of carotid stenosis safe and effective. Among the most important innovations are devices for distal and proximal embolic protection and new stent designs. This paper reviews these advances in the endovascular management of carotid artery stenosis within the context of the historical background. ABBREVIATIONS: ACAS, Asymptomatic Carotid Atherosclerosis Study ACST, Asymptomatic Carotid Surgery Trial CAS, carotid artery angioplasty and stenting CAVATAS, Carotid and Vertebral Transluminal Angioplasty Study CCA, common carotid artery CEA, carotid endarterectomy CREST, Carotid Revascularization Endarterectomy vs Stenting Trial ECA, external carotid artery ECST, European Carotid Surgery Trial EVA-3S, Endarterectomy vs Stenting in Patients with Symptomatic Severe Carotid Stenosis ICA, internal carotid artery ICSS, International Carotid Stenting Study IVUS, intravascular ultrasound MI, myocardial infarction NASCET, North American Symptomatic Carotid Endarterectomy Trial SAPPHIRE, Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy SPACE, Stent supported Percutaneous Angioplasty of the Carotid artery vs Endarterectomy

Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/02001/Endovascular_Advances_for_Extracranial_Carotid.12.aspx

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.

Cognitive therapy for people with schizophrenia spectrum disorders not taking antipsychotic drugs: a single-blind randomised controlled trial.
Unbound MEDLINE | Lancet journal articles

Antipsychotic drugs are usually the first line of treatment for schizophrenia; however, many patients refuse or discontinue their pharmacological treatment. We aimed to establish whether cognitive therapy was effective in reducing psychiatric symptoms in people with schizophrenia spectrum disorders who had chosen not to take antipsychotic drugs.We did a single-blind randomised controlled trial at two UK centres between Feb 15, 2010, and May 30, 2013. Participants aged 16-65 years with schizophrenia spectrum disorders, who had chosen not to take antipsychotic drugs for psychosis, were randomly assigned (1:1), by a computerised system with permuted block sizes of four or six, to receive cognitive therapy plus treatment as usual, or treatment as usual alone. Randomisation was stratified by study site. Outcome assessors were masked to group allocation. Our primary outcome was total score on the positive and negative syndrome scale (PANSS), which we assessed at baseline, and at months 3, 6, 9, 12, 15, and 18. Analysis was by intention to treat, with an ANCOVA model adjusted for site, age, sex, and baseline symptoms. This study is registered as an International Standard Randomised Controlled Trial, number 29607432.74 individuals were randomly assigned to receive either cognitive therapy plus treatment as usual (n=37), or treatment as usual alone (n=37). Mean PANSS total scores were consistently lower in the cognitive therapy group than in the treatment as usual group, with an estimated between-group effect size of -6·52 (95% CI -10·79 to -2·25; p=0·003). We recorded eight serious adverse events: two in patients in the cognitive therapy group (one attempted overdose and one patient presenting risk to others, both after therapy), and six in those in the treatment as usual group (two deaths, both of which were deemed unrelated to trial participation or mental health; three compulsory admissions to hospital for treatment under the mental health act; and one attempted overdose).Cognitive therapy significantly reduced psychiatric symptoms and seems to be a safe and acceptable alternative for people with schizophrenia spectrum disorders who have chosen not to take antipsychotic drugs. Evidence-based treatments should be available to these individuals. A larger, definitive trial is needed.National Institute for Health Research.


Original Article: http://www.unboundmedicine.com/medline/citation/24508320/Cognitive_therapy_for_people_with_schizophrenia_spectrum_disorders_not_taking_antipsychotic_drugs:_a_single_blind_randomised_controlled_trial_