Tuesday, October 14, 2014

[Comment] Therapy of amyotrophic lateral sclerosis remains a challenge

[Comment] Therapy of amyotrophic lateral sclerosis remains a challenge
The Lancet Neurology

Amyotrophic lateral sclerosis is a devastating fatal disease of motor neurons in the brain, brainstem, and spinal cord. It affects otherwise healthy people and can develop at any point in adulthood. Worldwide, more than 150 000 people die from the disease every year, on average 3 years after symptom onset. Laboratory and patient-oriented research during the past two decades has led to major improvements in our understanding of the pathogenesis of amyotrophic lateral sclerosis, including newly discovered genes, improved in-vitro and in-vivo modelling of the disease, generation of patient-derived motor neurons through induced pluripotent stem cell technology, the discovery of TDP43 protein aggregates in motor neurons, innovative imaging and whole-genome sequencing technology initiatives, the identification of endophenotypes, and the association of the disease with frontotemporal dementia.

Original Article: http://www.thelancet.com/journals/laneur/article/PIIS1474-4422(14)70179-6/fulltext?rss=yes

Concussion: Key Stakeholders and Multidisciplinary Participation in Making Sports Safe

Concussion: Key Stakeholders and Multidisciplinary Participation in Making Sports Safe
Neurosurgery - Most Popular Articles

image As unstructured play declines, organized sports leagues have become a highly popular form of physical activity in young people. As concussive injuries are garnering increased media attention and public awareness, there is a growing concern for athlete safety. Although athletic trainers and physicians play a large role in keeping athletes healthy and safe, this article investigates nontraditional, multidisciplinary teams that are involved in promoting athlete safety, including the role of equipment makers, coaches, referees, governing bodies of sport, lawmakers, and fans. As opposed to a focus on diagnosing or managing concussive injuries, this article seeks to promote injury prevention strategies. ABBREVIATIONS: NCAA, National Collegiate Athletic Association NFL, National Football League NHL, National Hockey League

Original Article: http://journals.lww.com/neurosurgery/Fulltext/2014/10001/Concussion___Key_Stakeholders_and.11.aspx