Neurosurgery Blog: Central nervous system metastases from castration-resistant prostate cancer in the docetaxel era

Abstract

Central nervous system (brain or leptomeningeal) metastases (BLm) are considered rare in castration-resistant prostate cancer (CRPC) patients. Now that docetaxel has become the reference drug for first-line treatment of CRPC, patients whose disease is not controlled by hormonal manipulations may live much longer than before and have higher risk of developing BLm. We retrospectively reviewed the records of all patients with CRPC attending our centres from 2002 to 2010, and identified all of those who were diagnosed as having BLm and received (or were considered to have been eligible to receive) docetaxel-based treatment. We identified 31 cases of BLm (22 brain metastases and 9 leptomeningeal metastases) with an incidence of 3.3%. BLm-free survival was 43.5 months, and survival after BLm discovery was 4 months. With six patients surviving for more than 1 year after developing BLm, the projected 1-year BL-S rate was 25.8%. The findings of our study may be relevant in clinical practice as they indicate that incidence of BLm in CRPC patients in the docetaxel era seems to be higher than in historical reports, meaning that special attention should be paid to the appearance of neurological symptoms in long-term CRPC survivors because they may be related to BLm.

Content Type Journal Article
Category Clinical Study – Patient Study
Pages 1-6
DOI 10.1007/s11060-011-0734-y
Authors
- Orazio Caffo, Department of Medical Oncology, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy
- Angela Gernone, Department of Medical Oncology, Civil Hospital, Bari, Italy
- Cinzia Ortega, Department of Medical Oncology, Institute for Cancer Research and Treatment, Candiolo, Italy
- Teodoro Sava, Department of Medical Oncology dO, Maggiore Hospital, Verona, Italy
- Giacomo Cartenì, Department of Medical Oncology, Cardarelli Hospital, Naples, Italy
- Gaetano Facchini, Medical Oncology Division – Uro-Gynaecological Department, National Cancer Institute of Napoli, Fondazione "G. Pascale", Naples, Italy
- Giovanni Lo Re, Department of Medical Oncology, Santa Maria degli Angeli Hospital, Pordenone, Italy
- Placido Amadio, Department of Medical Oncology, Garibaldi Hospital, Catania, Italy
- Roberto Bortolus, Department of Radiotherapy Oncology, National Cancer Institute, Aviano, Italy
- Vincenzo Pagliarulo, Department of Urology, University of Bari, Bari, Italy
- Veronica Prati, Department of Medical Oncology, Institute for Cancer Research and Treatment, Candiolo, Italy
- Antonello Veccia, Department of Medical Oncology, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy
- Enzo Galligioni, Department of Medical Oncology, Santa Chiara Hospital, Largo Medaglie d'Oro, 38100 Trento, Italy