Friday, November 18, 2011

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders

Nature Reviews Neuroscience 12, 723 (2011). doi:10.1038/nrn3114

Author: Berislav V. Zlokovic

The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) permeability and cerebral blood flow, and maintains the chemical composition of the neuronal 'milieu', which is required for proper functioning of neuronal






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