Accumulating evidence suggests that migraine is associated with progressive functional and structural changes in the brain. In the 2004 CAMERA-1 study, MRI scans of 295 randomly selected patients with migraine were compared with scans of 140 healthy controls. Patients with migraine more frequently had infarcts in the posterior circulation, hyperintense brainstem lesions (migraine with aura only), and deep white matter hyperintensities (women only) than did healthy controls. Higher attack frequencies were associated with higher risks of having changes in the brain, which suggests disease progression over time due to accumulation of the effect.
Júlio Leonardo B. Pereira
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