Thursday, December 13, 2012

[2012 Round-Up] Traumatic brain injury: networks and neuropathology

Although identification of pathological changes in mild traumatic brain injury (TBI) has posed challenges, 2012 has also been a year of advances and debate. Patients with mild TBI or concussion are generally thought to have a form of diffuse axonal injury, but this so-called stealth pathology is invisible to conventional imaging techniques. However, diffusion tensor imaging shows promise in elucidation of disruption of white matter tracts consistent with diffuse axonal injury. Previous diffusion tensor imaging studies were often based on the premise that damage to white-matter tracts was spatially homogeneous, meaning that signal changes were uniform among basic imaging units (voxels) along individual tracts.





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